High-Throughput Methods in the Discovery and Study of Biomaterials and Materiobiology

The complex interaction of cells with biomaterials (i.e., materiobiology) plays an increasingly pivotal role in the development novel implants, biomedical devices, and tissue engineering scaffolds to treat diseases, aid restoration bodily functions, construct healthy tissues, or regenerate diseased ones. However, conventional approaches are incapable screening huge amount potential material parameter combinations identify optimal cell responses involve a combination serendipity many series trial-and-error experiments. For advanced regenerative medicine, highly efficient bioanalysis platforms expected explore using combinatorial that offer desired microenvironments during healing, development, homeostasis. In this review, we first introduce materiobiology its high-throughput (HTS). Then present in-depth recent progress 2D/3D HTS gradient microarray) principle, preparation, for materiobiology, other technologies. Compendium Biomaterial Transcriptomics high content imaging, computational simulations, their translation toward commercial clinical uses highlighted. final section, current challenges future perspectives discussed. High-throughput experimentation within field enables elucidation relationships between biomaterial properties biological behavior thereby serves as tool accelerating high-performance biomaterials.